Wednesday, July 24, 2002

GENETIC DETAILS

Proc. Natl. Acad. Sci. USA, Vol. 99, Issue 15, 9882-9887, July 23, 2002
Developmental Biology
A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: Possible involvement in the genesis of the Philadelphia chromosome translocation
Giuseppe Saglio, et al.

...Evolutionary studies using fluorescence in situ hybridization identified the region as a duplicon, which transposed from the region orthologous to human 9q34 to chromosome 22 after the divergence of orangutan from the human-chimpanzee-gorilla common ancestor about 14 million years ago....